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UNC Researchers Close in on Cause of Runner's Knee

From professional athletes to weekend warriors, the condition known as “runner’s knee” is a painful and potentially debilitating injury suffered by millions of people — although until now, it has been unclear what causes it.

New research from the University has zeroed in on what appear to be the main culprits of the condition, formally known as patellofemoral pain syndrome.

The study is believed to be the first large, long-term project to track athletes from before they developed runner’s knee, said study co-author Darin Padua ’98 (MA), associate professor of exercise and sport science.

“Earlier studies have usually looked at people after the problem sets in,” Padua said. “That means that while previous research has identified possible risk factors related to strength and biomechanics, it’s been unclear whether those caused the injury or whether people’s muscles and the way they moved changed in response to their injury.”

The research appears in the November issue of the American Journal of Sports Medicine.

Runner’s knee — the bane of many types of exercise, from running to basketball to dance — affects one in four physically active people. If unchecked, it can lead to more serious problems, such as patellofemoral osteoarthristis.

“Patellofemoral pain syndrome can be devastating,” Padua said. “The pain can severely curtail a person’s ability to exercise, and the symptoms commonly reoccur. That said, athletes often have a high pain threshold and may ignore it. But if they do, their cartilage may break down — and if that gets to the point of bone-on-bone contact, nothing can be done to replace the damaged cartilage.”

Padua and his colleagues studied about 1,600 midshipmen from the U.S. Naval Academy. Researchers analyzed participants’ biomechanics when they enrolled at the academy, then followed them for several years to see whether they developed patellofemoral pain syndrome.

Forty participants (24 women and 16 men) developed the syndrome in the follow-up period. The study found that:

  • Participants with weaker hamstring muscles were 2.9 times more likely to develop the syndrome than those with the strongest hamstrings;
  • Those with weaker quadriceps muscles were 5.5 times more likely;
  • Those with a larger navicular drop (a measure of arch flattening when bearing weight) were 3.4 times more likely; and
  • Participants with smaller knee flexion angle (those whose knees bent less on landing during a jump test) were 3.1 times more likely.

Padua said the pain associated with the condition could be explained by those different factors coming together to create a focal point of pressure between the kneecap and the underlying bone.

“Overall, these people generally have weaker quads and hamstrings. As a result, they don’t bend their knees as much when doing tasks, such as running or jumping. That means the contact area between the kneecap and the femur is smaller, so pressure is focused and pinpointed on a smaller area.

“Also, the more a person’s arch falls when bearing weight, the more their whole leg may rotate inwards. That will mean their kneecap won’t track properly, leading to yet more pressure and more potential pain.”

Padua said the good news is that the study appears to confirm that if people can change the way they move and improve their leg strength, they can prevent or correct the problem.

Everyday athletes also can spot for themselves whether they are at risk: If their knee crosses over the big toe when squatting, if the arches of their feet collapse when landing from a jump and if they do not bend their knees much when they land, they stand a greater chance of developing the syndrome, Padua said.

The researchers are looking into which exercises are best for improving the biomechanics involved. They have developed a simple screening tool, called LESS (Landing Error Scoring System), for identifying people most at risk of runner’s knee and similar conditions and of suffering ACL (anterior cruciate ligament) injuries.


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